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FAM72 (p17) expression in the brain

FAM72 (p17) expression in the hippocampus of the brain. Immunohistochemical analysis of a wild-type mouse brain revealed that p17 is expressed in the hippocampus (a = CA1 region; b = dentate gyrus; c = CA3 region) and cortex (d). Scale

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The protein FAM72 (p17) signalling pathways in cancer

Schematic hypothesis of p17-mediated tumorigenesis by influencing p53 signalling pathways. During tomorigenesis p17 expression gets probably at two different loci (FAM72A/B) out of control. Upon DNA damage PPM1D regulates UNG2 action and suppresses BER through the modulation of various targets

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Analysis of structure and function of the gene FAM72

FAM72A­Zn2+ and RSM interactions. A) Zn2+-binding sites are shown on the developed 3D FAM72A protein structure. Suggested Zn2+-binding sites on the FAM72A protein are Csy18, Cys21, Cys74, and Cys77. B) The RSM ((2s)-2-(acetylamino)-Nmethyl-4-[(R)-methylsulfinyl] butanamide)-binding sites are shown on the developed

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