Predicted interactions between Tau protein, FKBP and CHIP in AD. FKBP12 catalyzes the hyperphosphorylated Tau assembly into PHF. The fate of HSP90-bound hyperphosphorylated Tau is determined by the binding of the HSP90 co-chaperone molecule. The binding of an FKBP51 co-chaperone will drive the accumulation of Tau, which is antagonized by FKBP52. In contrast, the binding of HSP90 to the CHIP co-chaperone will lead to hyperphosphorylated Tau proteasomal degradation.
The Ubiquitin-Proteasome System and Molecular Chaperone Deregulation in Alzheimer’s Disease.
Sulistio YA, Heese K.
Mol Neurobiol. 2015 Jan 7. [Epub ahead of print]