FAM72AZn2+ and RSM interactions. A) Zn2+-binding sites are shown on the developed 3D FAM72A protein structure. Suggested Zn2+-binding sites on the FAM72A protein are Csy18, Cys21, Cys74, and Cys77. B) The RSM ((2s)-2-(acetylamino)-Nmethyl-4-[(R)-methylsulfinyl] butanamide)-binding sites are shown on the developed 3D FAM72A protein structure. Suggested RSM-binding sites on FAM72A protein are Tyr83, Val85, Cys96, and Asn97.
Lead discovery and in silico 3D structure modeling of tumorigenic FAM72A (p17).
Pramanik S, Kutzner A, Heese K.
Tumour Biol. 36(1):239-49 (2015). (pdf)