Analysis of structure and function of the gene FAM72

Figure-Research-FAM72

FAM72A­Zn2+ and RSM interactions. A) Zn2+-binding sites are shown on the developed 3D FAM72A protein structure. Suggested Zn2+-binding sites on the FAM72A protein are Csy18, Cys21, Cys74, and Cys77. B) The RSM ((2s)-2-(acetylamino)-Nmethyl-4-[(R)-methylsulfinyl] butanamide)-binding sites are shown on the developed 3D FAM72A protein structure. Suggested RSM-binding sites on FAM72A protein are Tyr83, Val85, Cys96, and Asn97.

Reference:

Lead discovery and in silico 3D structure modeling of tumorigenic FAM72A (p17).
Pramanik S, Kutzner A, Heese K.
Tumour Biol. 36(1):239-49 (2015). (pdf)

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